Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep910 | Reproductive and Developmental Endocrinology | ECE2023

Undercarboxylated Osteocalcin/GPRC6A: A Bone Testis Crosstalk

Jawich Kenda , De Toni Luca , Al-Fahoum Sahar , AHalabi Marwan , Dinisio Andrea , Santa Rocca Maria , Ferlin Alberto

Purpose: Undercarboxylated-Osteocalcin (ucOCN), acting on its putative receptor GPRC6A, was shown to stimulate of testosterone (T) production by Leydig cells in rodents, in parallel with the hypothalamus-pituitary-gonadal axis (HPG) mediated by luteinizing hormone (LH). The aim of this cross-sectional study is to evaluate the association among serum ucOCN, rs2247911 polymorphism of GPRC6A gene and the endocrine/reproductive pattern in a cohort of infertile males, poss...